- A Visual Guide to Heart Disease
- Medical Illustrations of the Heart Image Collection
- Take the Heart Disease Quiz!
- What brand names are available for evolocumab?
- Is evolocumab available as a generic drug?
- Do I need a prescription for evolocumab?
- What are the uses for evolocumab?
- What are the side effects of evolocumab?
- What is the dosage for evolocumab?
- Which drugs or supplements interact with evolocumab?
- Is evolocumab safe to take if I'm pregnant or breastfeeding?
- What else should I know about evolocumab?
What is the dosage for evolocumab?
- The recommended subcutaneous dose for patients with heterozygous familial hypercholesterolemia or adults with heart problems related to excess cholesterol in the body is either 140 mg every 2 weeks or 420 mg once monthly.
- The recommended subcutaneous dosage in patients with homozygous familial hypercholesterolemia is 420 mg once monthly. LDL cholesterol levels should be measured 4 to 8 weeks after starting Repatha since response to therapy will depend on the degree of LDL-receptor function.
- LDL cholesterol levels should be measured within 4 to 8 weeks of starting therapy to assess response to treatment, and a decision should be made whether or not to adjust the dose.
- Repatha should only be injected subcutaneously into the thigh, abdomen, or upper arm. Injection sites should be rotated among different sites to prevent or reduce injection site reactions and irritation. Repatha should not be co-administered with other injectable drugs at the same injection site.
Which drugs or supplements interact with evolocumab?
No clinically significant drug-drug interactions are known for Repatha.
Quick GuideHeart Disease: Symptoms, Signs, and Causes
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.












