Repatha (evolocumab)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is the dosage for evolocumab?

  • The recommended subcutaneous dose for patients with heterozygous familial hypercholesterolemia or adults with heart problems related to excess cholesterol in the body is either 140 mg every 2 weeks or 420 mg once monthly.
  • The recommended subcutaneous dosage in patients with homozygous familial hypercholesterolemia is 420 mg once monthly. LDL cholesterol levels should be measured 4 to 8 weeks after starting Repatha since response to therapy will depend on the degree of LDL-receptor function.
  • LDL cholesterol levels should be measured within 4 to 8 weeks of starting therapy to assess response to treatment, and a decision should be made whether or not to adjust the dose.
  • Repatha should only be injected subcutaneously into the thigh, abdomen, or upper arm. Injection sites should be rotated among different sites to prevent or reduce injection site reactions and irritation. Repatha should not be co-administered with other injectable drugs at the same injection site.

Which drugs or supplements interact with evolocumab?

No clinically significant drug-drug interactions are known for Repatha.

Medically Reviewed by a Doctor on 9/22/2016

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