etodolac, Lodine (Discontinued) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Individuals taking oral blood thinners or anticoagulants (for example, warfarin [Coumadin]) should avoid etodolac because etodolac also thins the blood, and excessive blood thinning may lead to bleeding.
Persons who have more than three alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking etodolac or other NSAIDs.
PREGNANCY: There are no adequate studies of etodolac in pregnant women. NSAIDs may cause adverse cardiovascular effects in the fetus during late pregnancy.
NURSING MOTHERS: It is not known whether etodolac is excreted in human milk.
SIDE EFFECTS: The most common side effects from etodolac are rash, ringing in the ears, headaches, dizziness, drowsiness, abdominal pain, nausea, diarrhea, constipation, heartburn, fluid retention, and shortness of breath. NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury. Etodolac also may cause stomach and intestinal bleeding and ulcers. Sometimes, stomach ulceration and intestinal bleeding can occur without any abdominal pain. Black, tarry stools, weakness, and dizziness upon standing may be the only signs of the bleeding. People who are allergic to other NSAIDs should not use etodolac. NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients who already have impairment of kidney function or congestive heart failure, and treatment with NSAIDs in these patients should be done cautiously. Individuals with asthma are more likely to experience allergic reactions to etodolac and other NSAIDs. Fluid retention, blood clots, heart attacks, hypertension, and heart failure have also been associated with the use of NSAIDs.
Reference: FDA Prescribing Information
Last Editorial Review: 3/27/2013
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