etodolac, Lodine (Discontinued)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: etodolac
BRAND NAME: Lodine (Discontinued)
DRUG CLASS AND MECHANISM: Etodolac belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include ibuprofen (Motrin, Advil, Nuprin, etc.), naproxen (Aleve, Naprosyn), indomethacin (Indocin), nabumetone (Relafen) and numerous others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins which are chemicals that are responsible for pain and the fever and tenderness that often occur with inflammation. Etodolac blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. The FDA approved etodolac in January 1991.
GENERIC AVAILABLE: Yes
STORAGE: Capsules and tablets of etodolac should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).
PRESCRIBED FOR: Etodolac is used for the treatment of inflammation and pain caused by osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. It also is used for treating soft tissue injuries, such as tendinitis and bursitis, and menstrual cramps.
DOSING: The recommended doses for general pain relief when using immediate release capsules or tablets are 200-400 mg every 6-8 hours.
Arthritis is managed with 600-1000 mg given in 2 or 3 divided doses daily.
The maximum recommended dose is 1000 mg daily. Total daily doses exceeding 1000 mg have not been adequately evaluated; however, some patients may benefit from a total daily dose of 1200 mg.
The recommended dose when using extended relief tablets is 400-1000 mg once daily. Doses above 1200 mg have not been evaluated.
Etodolac should be taken with food and 8-12 oz of water to avoid stomach related side effects.
DRUG INTERACTIONS: Etodolac is associated with several suspected or probable interactions that affect the action of other drugs. The following examples are the most commonly suspected interactions.
Etodolac may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the elimination of lithium from the body by the kidneys. Increased levels of lithium may lead to lithium toxicity.
Etodolac may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation (lowering) of blood pressure.
When etodolac is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin), the blood levels of the methotrexate or aminoglycoside may increase, presumably because their elimination from the body is reduced. This may lead to more methotrexate or aminoglycoside-related side effects. Etodolac increases side effects of cyclosporine.
Individuals taking oral blood thinners or anticoagulants (for example, warfarin [Coumadin]) should avoid etodolac because etodolac also thins the blood, and excessive blood thinning may lead to bleeding.
Persons who have more than three alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking etodolac or other NSAIDs.
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