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ETIDRONATE/CALCIUM CARBONATE-ORAL (cont.)

OTHER USES: This drug may also be used for other medical conditions affecting the bones (e.g., Paget's disease).

HOW TO USE: You will take the etidronate portion of this medication for the first two weeks, then the calcium portion for the remainder of a 3 month cycle; then the cycle is repeated. If any of the information is unclear, consult your pharmacist. Take this medication by mouth usually once daily with a full glass (6-8 oz or 180-240 ml) of water unless your doctor directs you otherwise. After taking etidronate, do not lie down for at least 30 minutes. Avoid taking the etidronate portion of this product within 2 hours of food or any products containing iron, magnesium, calcium, or aluminum (e.g., antacids, laxatives, vitamins). Doing so may interfere with the absorption of the etidronate into your bloodstream (see Drug Interactions section). The calcium portion of this product may be taken with food. Use of vitamin D is also recommended, as it will aid in calcium absorption into your bloodstream. Consult your doctor to determine your daily calcium and vitamin D requirements. This product works gradually over time. It is very important to continue taking this medication even if you feel well. Most people with osteoporosis do not feel sick.

SIDE EFFECTS: Diarrhea, nausea, headache, stomach upset, gas, or constipation may occur. If any of these effects persist or worsen, notify your doctor. Promptly tell your doctor if any of these side effects occur: leg cramps, joint pain. Tell your doctor immediately if any of these serious side effects occur: vomiting, stomach pain. Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes, swelling in the mouth/tongue, trouble breathing. A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of: kidney problems, esophagus/stomach/bowel problems, certain bone diseases (untreated osteomalacia), any allergies. Caution is advised when using this drug in the elderly because they may be more sensitive to the side effects of the drug. This medication is not recommended for use during pregnancy. Consult your doctor for details. It is not known whether this drug passes into breast milk. Due to the potential risk to the infant, breast-feeding while using this drug is not recommended.



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