etidronate, Didronel (cont.)

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PRESCRIBED FOR: Etidronate is used for treating Paget's disease and preventing heterotopic ossification. Heterotopic ossification is a process in which bone is deposited in soft tissues and muscles, usually after hip replacement or spinal cord surgery. Non-FDA approved (off-label) uses include hypercalcemia (increased blood levels of calcium) associated with cancer, prevention of steroid induced osteoporosis, and postmenopausal osteoporosis.

SIDE EFFECTS: Common side effects of etidronate are:

Etidronate may worsen existing stomach or intestinal ulcers and can cause esophageal ulcers. Rarely, patients may experience jaw problems (osteonecrosis of the jaw) associated with delayed healing and infection after tooth extraction. Severe skin reactions, seizures, as well as decreased red and white blood cell levels occur rarely.



PREPARATIONS: Tablets: 200 and 400 mg.

STORAGE: Etidronate should be stored at room temperature, 15 C to 30 C (59 F to 86 F).

DOSING: The recommended dose for treating adults with Paget's disease is 5-10 mg/kg daily for up to 6 months or 11 to 20/mg/kg daily for up to 3 months. The maximum dose is 20 mg/kg daily.

The dose for preventing heterotopic ossification after hip replacement is 20 mg/kg daily one month before and for 3 months after surgery.

For prevention of heterotopic ossification after spinal cord injury the dose is 20 mg/kg daily for 2 weeks then 10 mg/kg daily for 10 weeks.

Food (especially, calcium rich foods such as dairy products), antacids, vitamins with mineral supplements, and certain medications can interfere with the absorption of etidronate. Therefore, etidronate should be taken on an empty stomach 2 hours before or after eating or taking other medications.

Medically Reviewed by a Doctor on 7/9/2015

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