etidronate, Didronel (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 200 and 400 mg.
STORAGE: Etidronate should be stored at room temperature, 15 C to 30 C (59 F to 86 F).
PRESCRIBED FOR: Etidronate is used for treating Paget's disease and preventing heterotopic ossification. Heterotopic ossification is a process in which bone is deposited in soft tissues and muscles, usually after hip replacement or spinal cord surgery. Non-FDA approved (off-label) uses include hypercalcemia (increased blood levels of calcium) associated with cancer, prevention of steroid induced osteoporosis, and postmenopausal osteoporosis.
DOSING: The recommended dose for treating adults with Paget's disease is 5-10 mg/kg daily for up to 6 months or 11 to 20/mg/kg daily for up to 3 months. The maximum dose is 20 mg/kg daily.
The dose for preventing heterotopic ossification after hip replacement is 20 mg/kg daily one month before and for 3 months after surgery.
For prevention of heterotopic ossification after spinal cord injury the dose is 20 mg/kg daily for 2 weeks then 10 mg/kg daily for 10 weeks.
Food (especially, calcium rich foods such as dairy products), antacids, vitamins with mineral supplements, and certain medications can interfere with the absorption of etidronate. Therefore, etidronate should be taken on an empty stomach 2 hours before or after eating or taking other medications.
DRUG INTERACTIONS: Calcium replacement products (for example, calcium chloride, calcium gluconate, and calcium carbonate [Caltrate 600, Caltrate 600 Plus D, Clatrate 600 Plus]) and antacids (for example, aluminum hydroxide) reduce the absorption and effects of etidronate.
PREGNANCY: The safety and effectiveness of etidronate has not been established in pregnant women.
NURSING MOTHERS: The safety and effectiveness of etidronate has not been established in nursing mothers.
SIDE EFFECTS: Common side effects of etidronate include headache, nausea, diarrhea, rash, hair loss, low calcium, low magnesium, low phosphate, reduced kidney function, leg cramps, and bone and joint pain. Etidronate may worsen existing stomach or intestinal ulcers and can cause esophageal ulcers. Rarely, patients may experience jaw problems (osteonecrosis of the jaw) associated with delayed healing and infection after tooth extraction. Severe skin reactions, seizures, as well as decreased red and white blood cell levels occur rarely.
Reference: FDA Prescribing Information
Last Editorial Review: 8/17/2012
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