GENERIC AVAILABLE: No
PREPARATIONS: 25 mg multiple use vial; 25 or 50 mg prefilled syringe; 50 mg prefilled autoinjector.
STORAGE: Sterile powder and pre-filled syringes should be refrigerated at 2 C to 8 C (36 F to 46 F). Reconstituted solutions made from the powder should be used as soon as possible but may be stored in the vial at 2 C - 8 C (36 F - 46 F) for 14 days.
PRESCRIBED FOR: Etanercept is used as primary treatment to reduce the pain, swelling, and tenderness of joints resulting from moderate to severe rheumatoid arthritis in adults. It also may be used when rheumatoid arthritis has not adequately responded to other drugs (called disease-modifying drugs for rheumatoid arthritis). For example, etanercept can be used in combination with methotrexate (Rheumatrex, Trexall) in patients who do not respond adequately to methotrexate alone.
Etanercept also is used to reduce the signs and symptoms of moderately to severely active, polyarticular-course, juvenile rheumatoid arthritis in children who have had an inadequate response to one or more disease-modifying drugs.
Etanercept is approved for the treatment of ankylosing spondylitis, psoriatic arthritis, and plaque psoriasis. It can prevent the progressive destruction of joints and improve physical function with psoriatic arthritis.
DOSING: Etanercept is injected under the skin.
- Adult rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis: 50 mg weekly
- Plaque psoriasis: 50 mg twice weekly for 3 months, followed by 50 mg once weekly
- Juvenile rheumatoid arthritis: 0.8 mg/kg weekly, with a maximum of 50 mg per week
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