estropipate, Ogen (cont.)

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Medical and Pharmacy Editor:
Medical and Pharmacy Editor:

Rifampin (Rifadin), barbiturates, carbamazepine (Tegretol), griseofulvin, phenytoin (Dilantin) and primidone (Mysoline), all can increase the elimination of estrogens by enhancing the liver's ability to metabolize (break down) the estrogens. Thus, concurrent use of these drugs and estrogens may result in reduction of the beneficial effects of estrogens.

PREGNANCY: Estrogens should be avoided during pregnancy due to an increased risk of fetal abnormalities.

NURSING MOTHERS: Estrogens are secreted in breast milk and cause unpredictable effects in the infant. They generally are not recommended for nursing mothers.

SIDE EFFECTS: Common side effects include break-through vaginal bleeding or spotting, loss of periods or excessively prolonged periods, breast pain, breast enlargement, and changes in sexuality (increased or decreased libido). Abdominal pain may result from obstruction of the gallbladder due to gallstones caused by the estrogen. Migraine headaches have been associated with estrogen therapy. Estrogens can cause sodium and fluid retention leading to swelling in the legs (edema). Melasma - tan or brown patches - may develop on the forehead, cheeks, or temples. These may persist even after the estrogen is stopped. Estrogens may cause an increase in the curvature of the cornea, and patients with contact lenses may develop intolerance to their lenses. Estrogens may increase risk of developing DVTs (deep vein thrombosis or blood clot) and endometrial cancer.

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 12/9/2014

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