estropipate, Ogen (cont.)

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Medical and Pharmacy Editor:

SIDE EFFECTS: Common side effects include break-through vaginal bleeding or spotting, loss of periods or excessively prolonged periods, breast pain, breast enlargement, and changes in sexuality (increased or decreased libido). Abdominal pain may result from obstruction of the gallbladder due to gallstones caused by the estrogen. Migraine headaches have been associated with estrogen therapy. Estrogens can cause sodium and fluid retention leading to swelling in the legs (edema). Melasma - tan or brown patches - may develop on the forehead, cheeks, or temples. These may persist even after the estrogen is stopped. Estrogens may cause an increase in the curvature of the cornea, and patients with contact lenses may develop intolerance to their lenses. Estrogens may increase risk of developing DVTs (deep vein thrombosis or blood clot) and endometrial cancer.

Reference: FDA Prescribing Information


Medically Reviewed by a Doctor on 8/25/2014


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