GENERIC NAME: estropipate
BRAND NAME: Ogen, ORTHO-EST
DRUG CLASS AND MECHANISM: Estropipate is a crystalline form of estrone, a form of estrogen. Estrogens occur in nature in several forms. In women with active menstrual cycles, the ovaries produce between 70 and 500 micrograms of one estrogen form, estradiol, daily. The estradiol is converted to estrone and to a lesser extent, estriol. After menopause, estrone is the most active circulating estrogen but is then is produced by the adrenal glands. Estrogens cause growth and development of female sex organs and maintains sexual characteristics, including underarm and pubic hair and the shape of body contours and the strength of bones. They increase secretions from the cervix and growth of the inner lining of the uterus (endometrium). They also reduce LDL-cholesterol ("bad" cholesterol) and increase HDL-cholesterol ("good" cholesterol) concentrations in the blood. Estrogens, when taken alone or in combination with a progestin, have been shown to reduce the risk for hip fractures due to osteoporosis by 25%. The FDA approved estropipate in June 1977.
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 0.75, 1.5, 3, and 6 mg or 0.625, 1.25 or 2.5, depending on the drug manufacturer.
STORAGE: Tablets should be stored below 25 C (77 F).
PRESCRIBED FOR: Estropipate is prescribed for treatment of symptoms associated with menopause (hot flashes, vaginal dryness), prevention of bone fractures associated with osteoporosis, low estrogen levels, and dysfunctional (excessive and painful) uterine bleeding.
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