estrogens conjugated, Premarin (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Estrogens can promote a build up of the lining of the uterus (endometrial hyperplasia) and increase the risk of endometrial cancer. (Women who have undergone surgical removal of the uterus--hysterectomy--are not susceptible to endometrial hyperplasia.) The addition of a progestin to estrogen therapy prevents the development of endometrial cancer.

The Women's Health Initiative found that postmenopausal women (50-79 years old) taking conjugated estrogens, 0.625 mg daily, in combination with medroxyprogesterone, 2.5 mg daily, for five years, had an increased risk of heart attacks, stroke, breast cancer, and blood clots, while postmenopausal women taking conjugated estrogens without progesterone experienced only increased strokes but not increased blood clots, heart disease, or breast cancer.

There was an increased risk of impaired cognition and/or dementia among women over age 65 treated with either estrogens or estrogens and medroxyprogesterone.

PRESCRIPTION: Yes.

GENERIC AVAILABLE: No.

PREPARATIONS: Tablets: 0.3, 0.45, 0.625, 0.9, and 1.25 mg. Vaginal cream: 0.625 mg per gm of cream. Injection: 25 mg per vial

STORAGE: Conjugated estrogen tablets and cream should be stored at room temperature, between 15 C -30 C (59 F - 86 F). The injection should be stored between 2 C - 8 C (36 F - 46 F).

PRESCRIBED FOR: Conjugated estrogens are used for treating the symptoms of menopause including hot flashes, vaginal dryness, and vaginal atrophy. If used solely for treating vaginal dryness and vaginal atrophy, the cream is preferred. They also are used as therapy when the body does not produce enough estrogen due to female castration (removal of the ovaries), ovarian failure or underdevelopment of hormone-secreting organs (hypogonadism).

Medically Reviewed by a Doctor on 12/19/2014


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