USES: This medication is used in women who still have a womb (uterus) to reduce hot flashes that occur with the "change of life" (menopause). It is a combination of two kinds of hormones, an estrogen (estradiol) and a progestin (levonorgestrel), and is given to women who no longer produce the proper amount.

HOW TO USE: Read the Patient Information Leaflet available from your pharmacist. Consult your doctor or pharmacist if you have any questions. One patch is usually worn for 1 week and then replaced, or use as directed by your doctor. Follow the dosing schedule carefully. Do not open the sealed pouch container until ready to use. Open the pouch and remove the patch from the protective liner. Apply the patch to a clean, dry area on the lower stomach below your belly button pressing firmly for about 10 seconds to make sure the patch stays on. Do not place the patch on the breast. Also, do not place the patch on oily, red, or damaged skin. Avoid applying to the waistline since tight clothing may rub the patch off. Do not put the patch on areas where sitting may loosen it. After 1 week, remove the patch; fold it in half with the sticky sides together and discard in the trash away from children and pets. Do not flush down the toilet. Apply a new patch to a different area to prevent skin irritation. If the area around the patch becomes red, itchy, or irritated, try a new site. If the irritation continues or becomes worse, notify your doctor promptly. If a patch falls off, reapply it or apply a new patch and wear it for the rest of the 7-day period. This medication should only be used as long as needed. You should talk to your doctor regularly (e.g., every 3 to 6 months) regarding the continued need for this treatment.

SIDE EFFECTS: See also Warning section. Dizziness, light-headedness, headache, stomach upset, bloating, nausea, weight changes, increased/decreased interest in sex, breast tenderness, or skin redness/irritation at the application site may occur. If any of these persist or worsen, notify your doctor or pharmacist promptly. Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (e.g., severe depression, memory loss), calf pain/swelling, sudden severe headache, chest pain, trouble breathing, one-sided weakness, slurred speech, vision changes (change in contact lens fit, loss of vision), swelling of hands or feet, stomach pain, vomiting, unusual vaginal discharge/itching/odor, yellowing eyes or skin. A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.