PRECAUTIONS: This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: undiagnosed abnormal vaginal bleeding, cancer (e.g., breast or ovary), blood clots, active/recent stroke or heart attack, liver disease. Tell your doctor your medical history (and family history), including: allergies, hysterectomy, gallbladder disease, high blood pressure, high blood levels of fats (triglycerides), asthma, migraine headaches, seizures, heart disease, kidney disease, diabetes, depression. Two-drug combination hormone replacement therapy (estrogen and progestin menopause HRT) can infrequently cause breast cancer, heart disease (CHD/MI), stroke, dementia, and blood clots in the lung (PE) or leg especially if used for a long period of time (greater than one year). Therefore, the risks of use of HRT for a long period of time must be discussed with your doctor . Use of two-drug HRT for short periods of time (less than one year) to relieve menopause symptoms may be considered. Discuss the risks and benefits with your doctor. Blood clots may be more likely to form during very long periods of sitting or if you are bedridden, as well as with certain types of surgery. If this applies to you, ask your doctor whether you should temporarily stop your medication. Cigarette smoking can increase the chance of blood clots, heart attacks, and strokes while using this product (especially in women past the age of 35). This product may cause a patchy, darkening of the skin on the face (melasma). Sunlight may intensify this darkening and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor or pharmacist regarding use of sunscreens and protective clothing. This product should not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. Both the estradiol and norethindrone acetate in this product are excreted into breast milk. Because of the potential risk to the infant, breast-feeding while using this product is not recommended. Consult your doctor before breast-feeding.