esterified estrogens and methyltestosterone, Estratest, Estratest HS (cont.)

Testosterone is the major male sex hormone that is responsible for many male sexual characteristics, but women also produce small amounts of testosterone. Following menopause, a woman's production of testosterone decreases. When testosterone in the form of methyltestosterone is added to estrogens, there may be a further alleviation of the hot flashes seen after menopause, and there also may be an improvement in a woman's sexual function.

GENERIC AVAILABLE: no

PRESCRIPTION: yes

PREPARATIONS: Estratest tablets: esterified estrogens 0.625mg plus methyltestosterone 1.25mg; esterified estrogens 1.25mg plus methyltestosterone 2.5mg. Estratest HS is one-half the strength of Estratest.

STORAGE: Tablets should be stored at 36-86°F (20-30°C).

PRESCRIBED FOR: Estratest is prescribed for the treatment of the common symptoms associated with menopause (e.g., hot flashes, vaginal dryness).

DOSING: Estratest usually is prescribed as 1 or 2 tablets daily for 21 consecutive days followed by 7 days without medication.

DRUG INTERACTIONS: For drug interactions for esterified estrogens, please read the esterified estrogens article.

Methyltestosterone can increase the effects of warfarin (Coumadin), increasing the risk of bleeding. Taking methyltestosterone and imipramine (Tofranil) together has led to paranoia in a few patients. Methyltestosterone can increase blood concentrations of cyclosporine (Sandimmune; Neoral), which can increase the risk of kidney damage.

PREGNANCY: Both methyltestosterone and estrogens should not be used during pregnancy due to an increased risk of fetal abnormalities.

NURSING MOTHERS: Estrogens are secreted in milk and cause unpredictable effects in the infant. They should not be used during breast-feeding.



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