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ERYTHROMYCIN STEARATE SUSPENSION-ORAL (cont.)

SIDE EFFECTS: May cause stomach upset, diarrhea, loss of appetite, nausea, vomiting and stomach cramps the first few days as your body adjusts to the medication. If these symptoms persist or become severe, inform your doctor. Notify your doctor if you develop symptoms of jaundice such as: dark urine, clay-colored stools, yellowing of eyes or skin. In the unlikely event you have an allergic reaction to this drug, seek medical attention immediately. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of: liver disease/jaundice, allergies. Use of this medication for prolonged or repeated periods may result in a secondary infection (e.g., oral, bladder or vaginal yeast infection) Caution is advised when this drug is used in infants. Though very unlikely to happen, a stomach problem called IHPS (infantile hypertrophic pyloric stenosis) has been noted. Contact your child's doctor immediately if the child has persistent vomiting or increased irritability. This drug should be used only if clearly needed during pregnancy. Small amounts of drug do appear in breast milk, so consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of all the drugs you may use, (prescription and nonprescription) especially of the following: carbamazepine, cyclosporine, theophylline, certain benzodiazepines (e.g., midazolam, triazolam), warfarin, felodipine (a calcium channel blocker), cisapride, birth control pills, corticosteroids (e.g., prednisone), digoxin, ergotamine-containing medication, sildenafil, certain live vaccines, disopyramide, phenytoin, all other antibiotics, certain "statin" drugs used for high cholesterol (e.g., atorvastatin, lovastatin, simvastatin). Other drugs besides erythromycin which may affect the heart rhythm (QTc prolongation in the EKG) include dofetilide, pimozide, quinidine, sotalol, procainamide, and sparfloxacin among others. QTc prolongation can infrequently result in serious, rarely fatal, irregular heartbeats. Consult your doctor or pharmacist for details. Ask for instructions about whether you need to stop any other QTc-prolonging drugs you may be using in order to minimize the risk of this effect. Do not start or stop any medicine without doctor or pharmacist approval.



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