DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: colchicine, eletriptan, ergot alkaloids (such as ergotamine, dihydroergotamine), digoxin, certain drugs for seizures (anti-convulsants such as carbamazepine, phenytoin, valproate), drugs that can change potassium levels (e.g., ACE inhibitors such as lisinopril), drugs which may affect the heart rhythm (QT prolonging drugs such as cisapride, disopyramide, pimozide), theophylline, live bacterial vaccines, warfarin, drugs affecting liver enzymes that remove erythromycin from your body (e.g., azole antifungals such as itraconazole/fluconazole, rifamycins including rifabutin, quinupristin-dalfopristin, calcium channel blockers such as diltiazem/verapamil).Many drugs besides erythromycin and those listed above may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, gatifloxacin, moxifloxacin, procainamide, propafenone, quinidine, sotalol, and thioridazine, among others. Therefore, before using erythromycin, report all medications you are currently using to your doctor or pharmacist.This drug can slow down the removal of other drugs from your body by affecting certain liver enzymes. Some examples of these affected drugs include alfentanil, bromocriptine, buspirone, certain benzodiazepines (alprazolam, midazolam, triazolam), caffeine-containing drugs, cilostazol, corticosteroids (e.g., prednisone), cyclosporine, eplerenone, certain drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), eszopiclone, felodipine, hexobarbital, certain "statin" drugs (such as atorvastatin, lovastatin, pravastatin, simvastatin), quetiapine, tacrolimus, tolterodine, vinblastine.Although most antibiotics probably do not affect hormonal birth control such as pills, patch, or ring, some antibiotics may decrease their effectiveness. This could cause pregnancy. Examples include rifamycins such as rifampin or rifabutin. Be sure to ask your doctor or pharmacist if you should use additional reliable birth control methods while using this antibiotic.This medication may interfere with certain laboratory tests (including urinary catecholamines), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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