erythromycin and benzoyl peroxide (gel or pak), Benzamycin

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

GENERIC AVAILABLE: Yes

PRESCRIPTION: Yes

PREPARATIONS: Benzamycin is dispensed in amounts of 46.6 gm containing 1.6 grams of erythromycin powder and 40 grams of benzoyl peroxide gel. The erythromycin powder is mixed with 6 ml of ethyl alcohol and then added to the benzoyl peroxide gel before it is dispensed to the patient. Benzamycin also is available as Benzamycin Pak, 60 individual-use packets containing both erythromycin and benzoyl peroxide as gels in separate compartment within the packet. Just prior to use, the packet is opened, and the gels are mixed.

STORAGE: Prior to mixing the erythromycin and benzoyl peroxide together, Benzamycin should be stored at room temperature, 15 C - 30 C (59 F - 86 F). After mixing, Benzamycin should be stored in the refrigerator between 2 C - 8 C (36 F – 46 F) and discarded after 3 months.

DOSING: The affected areas are washed and dried, and a thin layer of gel is applied twice daily (morning and evening) or as directed by a physician. The eyes, lips and nose should be avoided. Results should be seen within 4 to 6 weeks. This product is for external use only.

DRUG INTERACTIONS: Excessive skin irritation may occur if Benzamycin is used with other acne medications.

PREGNANCY: Safety of Benzamycin when used during pregnancy has not been established; however, the risk of side effects on the fetus is low because very little drug is absorbed through the skin.

NURSING MOTHERS: The possibility that infants will experience adverse effects due to the use of Benzamycin by a woman who is breastfeeding is very low since little drug is absorbed through the skin.

Medically reviewed by Eni Williams, PharmD

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 7/21/2015

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