Erythema Nodosum (cont.)

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What are the signs and symptoms of erythema nodosum?

Characteristic features of erythema nodosum include barely raised, tender, reddish nodules, most commonly below the knees in the front of the legs. They are typically painful and can slowly come and go.

There are several scenarios for the outcome of erythema nodosum. Typically, these areas of nodular tenderness are tender and inflamed off and on for a period of weeks. They usually then resolve spontaneously, each one of the little areas of inflammation shrinking down and then becoming flat rather than raised and inflamed. They leave a bruised appearance. Then, they resolve completely on their own. Other lesions can sometimes pop up elsewhere. This may occur for periods of weeks to months, and then they eventually go away. However, chronic erythema nodosum that may last for years is another pattern. Chronic erythema nodosum, with intermittent recurrences, can occur with or without an underlying disease present.

How is erythema nodosum diagnosed?

Usually, erythema nodosum is a straightforward, simple diagnosis for a doctor to make by examining a patient and noting the typical firm area of raised tenderness that is red along with areas which have had lesions resolved, which might show a bruised-like appearance. It does not typically require other investigative tests.

Sometimes a biopsy is done for confirmation. For example, if a patient presented with an isolated, nodule and a doctor was unable to make a diagnosis based on its appearance. The biopsy of the deeper layers of tissue of skin can prove that it is erythema nodosum.

Medically Reviewed by a Doctor on 12/4/2014

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