- What is erlotinib, and how does it work (mechanism of action)?
- What brand names are available for erlotinib?
- Do I need a prescription for erlotinib?
- What are the side effects of erlotinib?
- What is the dosage for erlotinib?
- Which drugs or supplements interact with erlotinib?
- Is erlotinib safe to take if I'm pregnant or breastfeeding?
- What else should I know about erlotinib?
What is the dosage for erlotinib?
The usual dose of erlotinib is 150 mg daily for NSCLC and 100 mg daily for pancreatic cancer. Erlotinib should be taken on an empty stomach at least one hour before or two hours after eating because food may reduce the absorption of erlotinib.
Which drugs or supplements interact with erlotinib?
CYP3A4 is an enzyme in the liver that breaks-down and helps to eliminate erlotinib from the body. Drugs that inhibit CYP3A4 can result in high levels of erlotinib in the body, and the high levels can result in toxicity from erlotinib. Such drugs include atazanavir (Reyataz), clarithromycin (Biaxin), indinavir (Crixivan), itraconazole (Sporanox), ketoconazole (Nizoral), nefazodone (Serzone), nelfinavir (Viracept), ritonavir (Norvir), saquinavir (Invirase; Fortovase), telithromycin (Ketek), and voriconazole (VFEND). In patients receiving these drugs, a lower dose of erlotinib may be needed to prevent toxicity.
Some drugs increase the elimination of erlotinib by increasing the activity of CYP3A4 enzymes. This reduces the levels of erlotinib in the body and may reduce its effect. Examples of such drugs include rifampicin (Rifadin), rifabutin (Mycobutin), rifapentine (Priftin), phenytoin (Dilantin), carbamazepine (Tegretol), phenobarbital and St. John's Wort. These drugs should be avoided in patients taking erlotinib, if possible. If alternative drugs are not an option, higher doses of erlotinib may be required.
Drugs that reduce the production of acid in the stomach will reduce the absorption of erlotinib. Therefore, proton pump inhibitors (PPI's, for example, omeprazole [Prilosec, Zegerid]) should not be administered with erlotinib, and erlotinib should be administered 10 hours before H2-receptor blockers (for example, ranitidine [Zantac]) or two hours after taking the H2-receptor blocker.
Administration of antacids should be separated from administration of erlotinib by several hours.
Quick GuidePancreatic Cancer Symptoms, Causes, and Treatment
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