erlotinib, Tarceva

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GENERIC NAME: erlotinib

BRAND NAME: Tarceva

DRUG CLASS AND MECHANISM: Erlotinib is a synthetic (man-made) oral drug that is used for treating cancer. It is approved for treatment of non-small cell lung cancer (NSCLC).

There are more than 1.2 million cases worldwide of lung cancer each year, causing one death every 3 seconds. According to the National Cancer Institute, lung cancer is responsible for nearly 30% of cancer deaths in the US. NSCLC is the most common form of lung cancer and accounts for almost 80% of all the cases.

Many cells, including cancer cells, have receptors on their surfaces for epidermal growth factor (EGF), a protein that is normally produced by the body and that promotes the growth and multiplication of cells. When EGF attaches to epidermal growth factor receptors (EGFRs), it causes an enzyme called tyrosine kinase to become active within the cells. Tyrosine kinase triggers chemical processes that cause the cells, including cancer cells, to grow, multiply, and spread. Erlotinib attaches to EGFRs, blocking the attachment of EGF and the activation of tyrosine kinase. This mechanism for stopping cancer cells from growing and multiplying is very different from the mechanisms of chemotherapy and hormonal therapy. Erlotinib was approved by the FDA in November of 2004.

GENERIC: No

PRESCRIPTION: Yes




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