ergotamine-caffeine-belladonna-pentobarb-oral, Cafatine PB, Micomp-PB, Urkaf-PB (cont.)

SIDE EFFECTS: Stomach upset, nausea, vomiting, drowsiness, frequent urination and constipation have been reported. If any of these effects continue or become bothersome, inform your doctor. Notify your doctor if you experience: muscle pain, weakness in the legs, tingling in the fingers or toes, fast/irregular heartbeat, dry mouth, blurred vision, painful urination. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor if you have: liver disease, kidney disease, heart disease, chest pain, high blood pressure, blood vessel disease, poor circulation, glaucoma, prostate trouble, ulcers, a severe infection, allergies (especially to caffeine). Use caution performing tasks requiring alertness if this medication makes you drowsy. Avoid the use of alcohol while taking this medication. This medication should not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. This combination drug contains ingredients that are excreted into breast milk and may have undesirable effects on a nursing infant. Breast-feeding should not be undertaken while using this medication.

DRUG INTERACTIONS: Infrequently, a very serious, life-threatening decrease in the amount of blood supply to the hands and feet (peripheral ischemia) and rarely to the brain can occur when this medication is taken with drugs that affect liver metabolism (e.g., potent CYP 3A4 enzyme inhibitors). Do not take this medication with macrolide antibiotics (e.g., erythromycin, clarithromycin, troleandomycin), protease inhibitors (e.g., ritonavir, nelfinavir, indinavir, amprenavir, saquinavir), azole antifungals (e.g., ketoconazole, itraconazole). Tell your doctor of all over-the-counter or prescription medications you may use including: propranolol, high blood pressure medication, blood thinners, sedatives, narcotic pain relievers, sleeping pills, nitrates (e.g., isosorbide, nitroglycerin), nefazodone, fluconazole, fluoxetine, fluvoxamine, zileuton, clotrimazole, other mild CYP 3A4 enzyme inhibitors. Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor instructs you otherwise. This drug may interfere with the effectiveness of birth control pills. Discuss using other methods of birth control with your doctor. Avoid drinking caffeine-containing beverages (coffee, tea, colas) and eating large amounts of chocolate. Because this medication contains caffeine, the risk of side effects may be increased. Do not start or stop any medicine without doctor or pharmacist approval.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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