Ergot

Are there any interactions with medications?



Medications for depression (Antidepressant drugs)
Interaction Rating: Major Do not take this combination.

Ergot increases a brain chemical called serotonin. Some medications for depression also increase the brain chemical serotonin. Taking ergot along with these medications for depression might increase serotonin too much and cause serious side effects including heart problems, shivering, and anxiety. Do not take ergot if you are taking medications for depression.

Some of these medications for depression include fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Tofranil), and others.



Medications for depression (MAOIs)
Interaction Rating: Major Do not take this combination.

Ergot increases a chemical in the brain. This chemical is called serotonin. Some medications used for depression also increase serotonin. Taking ergot with these medications used for depression might cause serious side effects including heart problems, shivering, and anxiety.

Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.



Dextromethorphan (Robitussin DM, and others)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Ergot can affect a brain chemical called serotonin. Dextromethorphan (Robitussin DM, others) can also affect serotonin. Taking ergot along with dextromethorphan (Robitussin DM, others) might cause too much serotonin in the brain and serious side effects including heart problems, shivering, and anxiety. Do not take ergot if you are taking dextromethorphan (Robitussin DM, and others).



Ergot Derivatives
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Ergot contains the same chemicals as ergot derivatives in prescription medications. Taking ergot supplements with prescription ergot derivatives can increase the effects and side effects of ergot.

Some of these ergot derivatives include bromocriptine (Parlodel), dihydroergotamine (Migranal, DHE-45), ergotamine (Cafergot), and pergolide (Permax).



Medications that decrease the breakdown of other medications in the liver (Cytochrome P450 3A4 [CYP3A4] inhibitors)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Some medications might decrease how quickly the liver breaks down ergot. Taking ergot along with some medications that decrease the break-down of other medications in the liver can increase the effects and side effects of ergot. Before taking ergot, talk to your healthcare provider if you are taking any medications that are changed by the liver.

Some medications that might decrease how quickly the liver breaks down ergot include amiodarone (Cordarone), clarithromycin (Biaxin), diltiazem (Cardizem), erythromycin (E-mycin, Erythrocin), indinavir (Crixivan), ritonavir (Norvir), saquinavir (Fortovase, Invirase), and many others.



Meperidine (Demerol)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Ergot increases a chemical in the brain called serotonin. Meperidine (Demerol) can also increase serotonin in the brain. Taking ergot along with meperidine (Demerol) might cause too much serotonin in the brain and serious side effects including heart problems, shivering, and anxiety.



Pentazocine (Talwin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Ergot increases a brain chemical called serotonin. Pentazocine (Talwin) also increases serotonin. Taking ergot along with pentazocine (Talwin) might increase serotonin too much. Too much serotonin can cause serious side effects including heart problems, shivering, and anxiety. Do not take ergot if you are taking pentazocine (Talwin).



Stimulant drugs
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Stimulant drugs speed up the nervous system. Speeding up the nervous system can make you feel jittery and speed up your heartbeat. Ergot might also speed up the nervous system. Taking ergot along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with ergot.

Some stimulant drugs include diethylpropion (Tenuate), epinephrine, phentermine (Ionamin), pseudoephedrine (Sudafed), and many others.



Tramadol (Ultram)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Tramadol (Ultram) can affect a chemical in the brain called serotonin. Ergot can also affect serotonin. Taking ergot along with tramadol (Ultram) might cause too much serotonin in the brain and side effects including confusion, shivering, stiff muscles, and other side effects.

Dosing considerations for Ergot.

The appropriate dose of ergot depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for ergot. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.