- What is epoetin alfa, and how does it work (mechanism of action)?
- What brand names are available for epoetin alfa?
- Is epoetin alfa available as a generic drug?
- Do I need a prescription for epoetin alfa?
- What are the side effects of epoetin alfa?
- What is the dosage for epoetin alfa?
- Which drugs or supplements interact with epoetin alfa?
- Is epoetin alfa safe to take if I'm pregnant or breastfeeding?
- What else should I know about epoetin alfa?
What is the dosage for epoetin alfa?
Epoetin alfa is administered intravenously or subcutaneously (under the skin) at 50-100 units/kg of body weight, three times weekly. The dose is tailored to each patient based on targeted hemoglobin levels. Adult patients with cancer receiving chemotherapy may be treated with 40,000 units weekly or 150 units/kg 3 times weekly.
Zidovudine treated patients should receive 100 units/kg 3 times weekly.
Surgery patients should receive 300 units/kg per day daily for 14 days or 600 units/kg weekly. The smallest effective dose should be used.
In clinical trials, the risk of death or serious heart problems, and stroke occurred more often when epoetin alpha was administered to target a hemoglobin level greater than 11 g/dL. Epoetin alfa vials should not be shaken since the drug may be damaged, and bubbles may form that prevent some of the drug from being drawn up into the syringe during injection. Iron stores should be evaluated before therapy and supplemental iron should be administered if needed.
Which drugs or supplements interact with epoetin alfa?
No clinical studies have been done to demonstrate epoetin alfa drug interactions.
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