- The recommended dose is the contents of 1 autoinjector (0.3 mg or 0.15 mg) injected under the skin or into the muscle of the thigh.
- The dose may be repeated after 5-15 minutes if symptoms persist.
- Patients that weigh 30 kg or more (approximately 66 pounds or more) should receive 0.3 mg (EpiPen) and patients that weigh 15 to 30 kg (33 pounds to 66 pounds) should receive 0.15 mg (EpiPen Jr).
- EpiPen may be injected through clothing if necessary.
- Administration of epinephrine to patients taking cardiac glycosides, diuretics (water pills), or drugs for treating irregular heartbeats (anti-arrhythmics) can cause the development of irregular heartbeats.
- The effects of epinephrine may be enhanced by medicines such as tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), levothyroxine (Synthroid, Levoxyl), and certain antihistamines.
- The treatment benefits of epinephrine can be reduced by beta-adrenergic blocking medicines such as propranolol (Inderal) and alpha-adrenergic blocking medicines such as phentolamine (Regitine, OraVerse).
- Some anti-migraine medications may also interfere with the benefits of epinephrine treatment.
PREGNANCY AND BREASTFEEDING SAFETY:
- Use of epinephrine has not been adequately evaluated in pregnant women. Use of epinephrine in animal studies was associated with birth defects. Epinephrine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
- It is not known if epinephrine is excreted in breast milk. Since many drugs are excreted in human milk and have the potential of causing harm to the nursing infant, caution should be used when epinephrine is administered to a nursing mother.
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