EpiPen (epinephrine auto-injector, EpiPen Jr)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: John P. Cunha, DO, FACOEP
    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.

What is the dosage for epinephrine auto-injector?

  • The recommended dose is the contents of 1 autoinjector (0.3 mg or 0.15 mg) injected under the skin or into the muscle of the thigh.
  • The dose may be repeated after 5-15 minutes if symptoms persist.
  • Patients that weigh 30 kg or more (approximately 66 pounds or more) should receive 0.3 mg (EpiPen) and patients that weigh 15 to 30 kg (33 pounds to 66 pounds) should receive 0.15 mg (EpiPen Jr).
  • EpiPen may be injected through clothing if necessary.

Which drugs or supplements interact with epinephrine auto-injector?

  • Administration of epinephrine to patients taking cardiac glycosides, diuretics (water pills), or drugs for treating irregular heartbeats (anti-arrhythmics) can cause the development of irregular heartbeats.
  • The effects of epinephrine may be enhanced by medicines such as tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), levothyroxine (Synthroid, Levoxyl), and certain antihistamines.
  • The treatment benefits of epinephrine can be reduced by beta-adrenergic blocking medicines such as propranolol (Inderal) and alpha-adrenergic blocking medicines such as phentolamine (Regitine, OraVerse).
  • Some anti-migraine medications may also interfere with the benefits of epinephrine treatment.
Medically Reviewed by a Doctor on 8/26/2016

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