Epclusa (sofosbuvir and velpatasvir)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

GENERIC NAME: sofosbuvir and velpatasvir





  • Epclusa is used to treat chronic hepatitis C virus genotype 1, 2,3,4,5 or 6 infection in adults without cirrhosis or with compensated cirrhosis.
  • It also may be combined with ribavirin (Rebetol) for treatment of adults with decompensated cirrhosis.


Common side effects of Epclusa include:

Other side effects of Epclusa include:

Other less common side effects of Epclusa include:

  • Increased blood levels of lipase
  • Increased blood levels of creatinine kinase
  • Increased blood levels of indirect bilirubin

Possible serious side effects include:

  • There is an increased risk of low heart rate (bradycardia) when Epclusa is combined with amiodarone (Cordarone).
Medically Reviewed by a Doctor on 7/13/2016

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