Eosinophilic Fasciitis (cont.)

Medical Author:
Medical Editor:

What is the treatment for eosinophilic fasciitis?

Treatment of eosinophilic fasciitis is directed at eliminating the tissue inflammation and includes aspirin, other anti-inflammatory drugs (NSAIDs), and cortisone. Many patients will improve spontaneously. Others can be afflicted with persistent tissue and joint pain, in addition to thickening of the involved tissues.

For aggressive eosinophilic fasciitis, cortisone medications (such as prednisone and prednisolone) are sometimes initially administered intravenously. Also considered are immune-suppression medications (such as methotrexate [Rheumatrex, Trexall], cyclophosphamide [Cytoxan], and penicillamine [Depen, Cuprimine]). More recently, mycophenolate mofetil (Cellcept) and rituximab (Rituxan) are being studied as potential therapies.

Medical research has shown that immune-suppression drugs, such as methotrexate, can reduce both the immune inflammation and the need for continued cortisone medications.

What specialists treat eosinophilic fasciitis?

Reader Stories

Eosinophilic fasciitis is treated by pediatricians, internists, dermatologists, and rheumatologists; occasionally, surgeons are consulted for deep biopsies and joint contractures.

What is the prognosis (outlook) for eosinophilic fasciitis?

The outlook for eosinophilic fasciitis is generally good, particularly if treated aggressively and early. Along with medications, physical therapy can be required for optimal rehabilitation. Poor function, however, is not uncommon, especially in children. Those with arthritis, atrophy of muscle, scarring limiting joint range of motion (contracture), and shortening of limb length tend to do worse.

Is it possible to prevent eosinophilic fasciitis?

Because we do not yet know the cause of eosinophilic fasciitis, it cannot be prevented.


Henning, Peter M. "Eosinophilic Fasciitis." Medscape.com. Mar. 3, 2015. <http://emedicine.medscape.com/article/329515-overview>.

Medically Reviewed by a Doctor on 11/16/2015

Patient Comments

Viewers share their comments

Eosinophilic Fasciitis (Shulman's Syndrome) - Symptoms and Signs Question: What symptoms and signs did you experience with eosinophilic fasciitis?
Eosinophilic Fasciitis (Shulman's Syndrome) - Treatment Question: What treatment(s) have you received for eosinophilic fasciitis?