DRUG INTERACTIONS: Medications that increase the risk of bleeding will add to the effects of enoxaparin and further increase the risk of bleeding that is associated with enoxaparin. Such medications include aspirin, clopidogrel (Plavix), warfarin (Coumadin), other anticoagulants, and nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin; Advil), naproxen (Naprosyn), diclofenac (Voltaren), and others.
PREGNANCY: Enoxaparin does not cross the placenta and shows no evidence of effects on the fetus. It often is used during pregnancy as an alternative to oral anticoagulants such as warfarin (Coumadin), which cannot be safely used during pregnancy.
Enoxaparin multiple-dose vials contain benzyl alcohol as a preservative. Benzyl alcohol has been associated with a fatal "gasping syndrome" in premature neonates. Enoxaparin vials preserved with benzyl alcohol should be used with caution in pregnant women and only if clearly needed because benzyl alcohol may cross the placenta.
NURSING MOTHERS: It is not known if enoxaparin is excreted in breast milk. Since most medicines are excreted in breast milk, it is recommended that women receiving enoxaparin should not breastfeed.
Reference: FDA Prescribing Information
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