enoxaparin, Lovenox (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DRUG INTERACTIONS: Medications that increase the risk of bleeding will add to the effects of enoxaparin and further increase the risk of bleeding that is associated with enoxaparin. Such medications include aspirin, clopidogrel (Plavix), warfarin (Coumadin), other anticoagulants, and nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin; Advil), naproxen (Naprosyn), diclofenac (Voltaren), and others.

PREGNANCY: Enoxaparin does not cross the placenta and shows no evidence of effects on the fetus. It often is used during pregnancy as an alternative to oral anticoagulants such as warfarin (Coumadin), which cannot be safely used during pregnancy.

NURSING MOTHERS: It is not known if enoxaparin is excreted in breast milk. Since most medicines are excreted in breast milk, it is recommended that women receiving enoxaparin should not breastfeed.

SIDE EFFECTS: The most common side effect associated with enoxaparin is bleeding. Fever, nausea, diarrhea, and fluid retention are common. Less commonly, enoxaparin can induce abnormal liver tests in the blood, suggesting mild damage to the liver, and a reduction in blood platelets and red blood cells. Mild local irritation, pain, hematoma, ecchymosis, and erythema may occur at the site of injection. Hypersensitivity reactions also may occur.

Reference: FDA Prescribing Information


Last Editorial Review: 3/28/2012



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