DOSAGE: Lovenox is administered by injection under the skin (subcutaneous) or intravenously.
- Preventing deep vein thrombosis after abdominal surgery: 40 mg subcutaneous injection once daily.
- Preventing deep vein thrombosis after knee replacement: 30 mg subcutaneous injection every 12 hours.
- Preventing deep vein thrombosis after hip replacement: 30 mg every 12 hours or 40 mg once daily by subcutaneous injection.
- Preventing deep vein thrombosis in ill patients with limited mobility: 40 mg subcutaneous injection once daily.
- Treatment of deep vein thrombosis or pulmonary embolism: 1 mg/kg every 12 hours or 1.5 mg/kg once daily by subcutaneous injection.
- Outpatient treatment of deep vein thrombosis: 1 mg/kg subcutaneous injection every 12 hours.
- Treatment of severe heart attacks (ST elevation myocardial infarction or STEMI): For patients under the age of 75, 30 mg intravenously plus 1 mg/kg subcutaneously followed by 1 mg/kg every 12 hours (maximum of 100 mg for each of the first two subcutaneous doses only). For patients over age 75, 0.75 mg/kg subcutaneously every 12 hours (maximum of 75 mg for each of the first two subcutaneous doses only). All patients should receive aspirin. Doses should be reduced in patients with impaired kidney function.
- Treatment of chest pain (unstable angina) or mild heart attack (non-Q-wave myocardial infarction): 1 mg/kg subcutaneously every 12 hours with aspirin.
- For coronary artery stent procedures (percutaneous coronary intervention or PCI): Patients should receive 0.3 mg/kg during stent placement if the last dose of Lovenox was administered more than 8 hours before the procedure.
- Medications that increase the risk of bleeding will add to the effects of Lovenox and further increase the risk of bleeding that is associated with Lovenox. Such medications include aspirin, clopidogrel (Plavix), warfarin (Coumadin), other anticoagulants, and nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin; Advil), naproxen (Naprosyn), diclofenac (Voltaren), and others.
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