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November 25, 2009
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Endometrial Biopsy (cont.)

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Why is endometrial biopsy done?

An endometrial biopsy is most often performed to help determine the cause of abnormal uterine bleeding. It can also be done to help evaluate the cause of infertility, test for uterine infections, and even monitor the response to certain medications.

Endometrial biopsy has many advantages over the more complicated procedure known as dilation and curettage (D&C), which is a more extensive removal of the uterine lining that requires dilation of the cervical opening with special instruments. Unlike D&C, endometrial biopsy may be performed in the doctor's office and typically does not require anesthesia or hospitalization.

Endometrial biopsy cannot be performed during pregnancy, and sometimes may not be recommended when certain other conditions are present, including cancer of the cervix or abnormal narrowing (stenosis) of the cervical opening.

How is an endometrial biopsy performed?

Endometrial biopsy is most often done in the physician's office, but it can be performed on women in the hospital. The patient lies on the examining table in a position similar to that used for obtaining Pap smears. The doctor uses a speculum to open the vaginal canal and visualize the cervix, the opening to the uterus. During endometrial biopsy the doctor inserts a thin plastic or metal tubular device through the cervix into the uterus to remove a tiny piece of the inner lining tissue.

Picture of the female reproductive system

Usually no anesthesia is required, but taking a nonsteroidal anti-inflammatory medication (NSAID) 30 to 60 minutes prior to the procedure can help reduce cramping and pain. In some cases, a small amount of lidocaine anesthetic is inserted into the uterine cavity to minimize discomfort.

What are the risks of endometrial biopsy?

There are very few risks with endometrial biopsy. The leading risk is pain or cramping, but this typically subsides rapidly following the procedure. Other less common risks are feeling faint or light-headed, possible infection, bleeding, and rarely, perforation of the uterus.


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Suggested Reading by Our Doctors
MedicineNet Doctors
  • Dilation and Curettage (D&C) - Read about dilation and Curettage (D&C), a procedure performed for a variety of reasons including determining the cause of abnormal uterine (vaginal) bleeding, tissue removal after miscarriage, or abortion.
  • Endometriosis - Lern about endometriosis symptoms like pelvic pain, infertility, diarrhea, constipation, lower back pain, abdominal pain, irregular or heavy menstrual bleeding, and even blood in the urine.
  • Endometrial Ablation - Read about endometrial ablation, a procedure performed to treat abnormal bleeding of the uterus. During the procedure the lining tissues of the uterus are destroyed.

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