enalapril and hydrochlorothiazide, Vaseretic (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

In rare instances

  • liver dysfunction and skin yellowing (jaundice) have been reported with ACE inhibitors.
  • In susceptible individuals ACE inhibitors may reduce kidney function. Enalapril may cause hypersensitivity (allergic) reactions and angioedema (swelling of face, lips, tongue, throat).

Side effects of HCTZ include:

Patients allergic to sulfa may also be allergic to HCTZ because of the similarity in the chemical structure of the medications.



PREPARATIONS: Tablets (mg enalapril/mg HCTZ): 5/12.5 and 10/25

STORAGE: Vaseretic should be stored at 15C to 30 C (59 F to 86 F) and protected from excessive light and humidity.

DOSING: Patients who have not adequately responded to enalapril or HCTZ alone may be started on 10/25 mg/mg of Vaseretic. The dose may be increased after 2-3 weeks if adequate. The maximum dose is 2 tablets of 10/25 mg/mg once daily.

DRUG INTERACTIONS: Enalapril may increase potassium levels (hyperkalemia) in blood. Therefore, there is an increased risk of hyperkalemia when enalapril is given with potassium supplements or drugs that increase potassium levels, for example, spironolactone (Aldactone).

Medically Reviewed by a Doctor on 7/9/2015

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