enalapril and hydrochlorothiazide, Vaseretic

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GENERIC NAME: enalapril and hydrochlorothiazide

BRAND NAME: Vaseretic

DRUG CLASS AND MECHANISM: Vaseretic is a combination of enalapril and hydrochlorothiazide (HCTZ) and is used for treating high blood pressure (hypertension). It is in a class of drugs called angiotensin converting enzyme (ACE) inhibitors. ACE is an enzyme in the body that causes the formation of angiotensin II. Angiotensin II causes the muscles surrounding the arteries in the body to contract, thereby narrowing the arteries and elevating the blood pressure. ACE inhibitors such as enalapril (Vasotec) lower blood pressure by preventing the formation of angiotensin II thereby relaxing the arteries.

HCTZ is a diuretic (water pill) used for treating high blood pressure and accumulation of fluid. It works by blocking salt and water reabsorption in the kidneys, thus causing increased urine output (diuresis). The mechanism of its action in lowering high blood pressure is not well understood. The combination of enalapril and HCTZ reduces blood pressure better than either drug alone. The FDA approved Vaseretic in October 1986.

PRESCRIBED FOR: Vaseretic is used for treating high blood pressure.

SIDE EFFECTS: The side effects of the Vaseretic are similar to the side effects of the individual component drugs:

  • A dry, persistent cough has been reported commonly with the use of ACE inhibitors. Coughing resolves after discontinuing the medication.
Medically Reviewed by a Doctor on 7/9/2015

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