enalapril and hydrochlorothiazide, Vaseretic

Pharmacy Author:
Medical and Pharmacy Editor:

GENERIC NAME: enalapril and hydrochlorothiazide

BRAND NAME: Vaseretic

DRUG CLASS AND MECHANISM: Vaseretic is a combination of enalapril and hydrochlorothiazide (HCTZ) and is used for treating high blood pressure (hypertension). It is in a class of drugs called angiotensin converting enzyme (ACE) inhibitors. ACE is an enzyme in the body that causes the formation of angiotensin II. Angiotensin II causes the muscles surrounding the arteries in the body to contract, thereby narrowing the arteries and elevating the blood pressure. ACE inhibitors such as enalapril (Vasotec) lower blood pressure by preventing the formation of angiotensin II thereby relaxing the arteries.

HCTZ is a diuretic (water pill) used for treating high blood pressure and accumulation of fluid. It works by blocking salt and water reabsorption in the kidneys, thus causing increased urine output (diuresis). The mechanism of its action in lowering high blood pressure is not well understood. The combination of enalapril and HCTZ reduces blood pressure better than either drug alone. The FDA approved Vaseretic in October 1986.

GENERIC AVAILABLE: Yes

PRESCRIPTION: Yes

PREPARATIONS: Tablets (mg enalapril/mg HCTZ): 5/12.5 and 10/25

STORAGE: Vaseretic should be stored at 15C to 30 C (59 F to 86 F) and protected from excessive light and humidity.

Medically Reviewed by a Doctor on 3/8/2013



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.


Back to Medications Index