Zepatier (elbasvir and grazoprevir)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is Zepatier, and how does it work?

Zepatier is an oral tablet containing two drugs used for the treatment of chronic infection with the hepatitis C virus (HCV), genotype 1 and 4 in adults. The components belong to a class of drugs called direct-acting antiviral agents. Similar drugs include:

Zepatier contains elbasvir and grazoprevir. Elbasvir directly blocks replication of HCV by interfering with a hepatitis C virus enzyme called NS5A. Grazoprevir is an inhibitor of another hepatitis C virus enzyme called NS3/4A, which also is needed for viral replication. Both drugs in Zepatier interfere with enzymes needed by hepatitis C virus to multiply and make new viruses, thus reducing the overall viral load. The efficacy of Zepatier has been established in subjects with hepatitis C virus genotypes 1 and 4.

Zepatier may be administered with or without ribavirin. In clinical studies, 95% of patients who were not previously treated for their hepatitis C virus were cured after 12 weeks of Zepatier treatment. Cure was defined as undetectable levels of hepatitis C virus in the blood when measured three months after the completion of treatment. The FDA approved Zepatier in January, 2016.

What brand names are available for Zepatier?

  • Zepatier is the brand name for the combination of two drugs, elbasvir and grazoprevir, available in the US.
Medically Reviewed by a Doctor on 1/27/2017

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