- What is Zepatier, and how does it work?
- What brand names are available for elbasvir and grazoprevir?
- Is Zepatier available as a generic drug?
- Do I need a prescription for Zepatier?
- What are the uses for Zepatier?
- What are the side effects of Zepatier?
- What is the dosage for Zepatier?
- Which drugs or supplements interact with Zepatier?
- Is Zepatier safe to take during pregnancy or while breastfeeding?
- What else should I know about Zepatier?
What is Zepatier, and how does it work?
Zepatier is an oral tablet containing two drugs used for the treatment of chronic infection with the hepatitis C virus (HCV), genotype 1 and 4 in adults. The components belong to a class of drugs called direct-acting antiviral agents. Similar drugs include:
- boceprevir (Victrelis)
- sofosbuvir (Sovaldi)
- simeprevir (Olysio)
- telaprevir (Incivek),
- Viekira Pak (ombitasvir, paritaprevir, ritonavir, dasabuvir)
- ledipasvir and sofosbuvir (Harvoni)
Zepatier contains elbasvir and grazoprevir. Elbasvir directly blocks replication of HCV by interfering with a hepatitis C virus enzyme called NS5A. Grazoprevir is an inhibitor of another hepatitis C virus enzyme called NS3/4A, which also is needed for viral replication. Both drugs in Zepatier interfere with enzymes needed by hepatitis C virus to multiply and make new viruses, thus reducing the overall viral load. The efficacy of Zepatier has been established in subjects with hepatitis C virus genotypes 1 and 4.
Zepatier may be administered with or without ribavirin. In clinical studies, 95% of patients who were not previously treated for their hepatitis C virus were cured after 12 weeks of Zepatier treatment. Cure was defined as undetectable levels of hepatitis C virus in the blood when measured three months after the completion of treatment. The FDA approved Zepatier in January, 2016.
What brand names are available for Zepatier?
- Zepatier is the brand name for the combination of two drugs, elbasvir and grazoprevir, available in the US.
Is Zepatier available as a generic drug?
- No, this drug is not available as a generic.
Do I need a prescription for Zepatier?
- Yes, you need a prescription for this drug.
What are the uses for Zepatier?
- Zepatier is used with or without ribavirin (Rebetrol) for the treatment of chronic hepatitis C virus (HCV) types 1 or 4 infection in adults.
What are the side effects of Zepatier?
Common side effects include:
Other side effects include:
- Abdominal pain
- Anemia (when combined with ribavirin)
- Elevations in levels of liver enzymes
- Increased bilirubin
- Joint pain
- Shortness of breath
- Reactivation of hepatitis B virus infection (HBV)
Quick GuideHepatitis C (Hep C) Symptoms and Treatment
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