efinaconazole, Jublia

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

  • Medical Author: Omudhome Ogbru, PharmD
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

GENERIC NAME: efinaconazole

BRAND NAME: Jublia

DRUG CLASS AND MECHANISM: Efinaconazole is a topical (applied to the skin) antifungal used for the local treatment of fungal infections of the toenails. Efinaconazole destroys fungal cells by inhibiting fungal lanosterol 14α-demethylase, an enzyme required to make ergosterol, an important fungal cell wall component. Without cell walls fungus cannot survive. Efinaconazole was approved by the FDA in June, 2014.

PRESCRIBED FOR: Efinaconazole is a prescription medicine used to treat fungal infections of the toenails. It is FDA approved for the treatment of onychomycosis of the toenails due to Trichophyton rubrum and Trichophyton mentagrophytes.

SIDE EFFECTS: The most common side effects of treatment are mainly irritation of the area(s) efinaconazole is applied to. Side effects include:

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

PREPARATIONS: Topical solution: 10%

STORAGE: Efinaconazole should be stored at room temperature, from 15 C to 30 C (59 C to 86 F). Efinaconazole is flammable and should be protected from heat or flames. Efinaconazole containers should be stored in an upright position. Keep efinaconazole and all medications out of the reach of children.

DOSING: Efinaconazole is applied to the affected toenail(s) once daily for 48 weeks. When applying efinaconazole, patients should make sure that the toenails, toenail beds, and surrounding skin are completely covered. For best results, apply efinaconazole to dry toenails. Patients should wait for at least 10 minutes after showering, bathing, or washing before applying efinaconazole. Patients should avoid pedicures, use of nail polish, or cosmetic nail products while using efinaconazole. Efinaconazole is only intended for use on toenails and surrounding skin.

Quick GuideNail Color and Texture: What Nails Say About Your Health

Nail Color and Texture: What Nails Say About Your Health
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