efavirenz, Sustiva (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

NURSING MOTHERS: It is not known whether efavirenz is excreted in human breast milk. HIV-infected mothers should not breastfeed because of the risk of transmitting HIV to an infant that is not infected.

SIDE EFFECTS: The most common side effects of efavirenz are rash, dizziness, confusion, insomnia, headaches, diarrhea, nausea, and vomiting. Other side effects include muscle pain (myalgia), abnormal heartbeats, liver failure, and increased cholesterol and triglyceride levels. Drowsiness, abnormal dreams, hallucinations, and difficulty concentrating may occur. Serious psychiatric adverse effects such as depression, suicidal thoughts, manic reactions, and aggressive behavior have been reported in patients taking efavirenz. Immune reconstitution syndrome which is an inflammatory response to infection may occur in patients treated with combination antiretroviral therapy.

Reference: FDA Prescribing Information

Last Editorial Review: 1/23/2013

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