efalizumab, Raptiva

What is the dosage for efalizumab?

Efalizumab is given as weekly subcutaneous (beneath the skin) injections. The first dose is 0.7 mg per kilogram of body weight (1 kilogram equals 2.2 pounds). Thereafter, each weekly dose is 1 mg per kilogram (up to a maximum single dose of 200 mg).

Efalizumab should be administered using the disposable syringe and needles provided in the kit. The cap on the pre-filled syringe containing sterile water should be removed. Thereafter, the needle is attached to the syringe. Remove the plastic cap protecting the rubber stopper of the efalizumab vial and wipe the top of the rubber stopper with one of the provided alcohol swabs. After cleaning with the alcohol swab, do not touch the top of the vial. To prepare the efalizumab solution, slowly inject the 1.3 mL of sterile water in the provided pre-filled syringe into the efalizumab vial. Swirl the vial with a gentle circular motion to dissolve the product. Do not shake. This procedure should be done immediately before each use, and the solution that is made should be used only once. If it is not used immediately after it is made, store at room temperature and use within 8 hours. Following administration, discard any unused reconstituted efalizumab solution. Potential sites for injection include the thigh, abdomen, buttocks, or upper arm. Injection sites should be rotated.

Which drugs or supplements interact with efalizumab?

The safety and efficacy of efalizumab in combination with other immune-suppressing medicines have not been evaluated. It is recommended that patients receiving other immune-suppressing medicines should not receive efalizumab because of the possibility of increasing the risks of infections and tumors. The safety and efficacy of vaccines administered to patients being treated with efalizumab also have not been studied. Some vaccines consisting of live viruses which have been rendered inactive (attenuated) should not be used in patients taking efalizumab

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