Persistent Depressive Disorder Treatment
Selective Serotonin Reuptake Inhibitor Drugs (SSRIs)
SSRIs were developed more recently than TCAs and are the most widely used class of antidepressants. They work by increasing the level of serotonin in the brain. Unlike MAOIs and TCAs, they do not significantly affect norepinephrine levels in the brain. SSRIs also have fewer and milder side effects, fewer drug interactions, and are much less likely to be associated with suicide than TCAs.