dutasteride (Avodart)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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Patients must contact their healthcare professional if unusual reactions to dutasteride occur.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Dutasteride is available as 0.5 mg liquid-filled capsules.

STORAGE: Dutasteride capsules should be stored between 15 C to 30 C (59 F to 86 F).

DOSING: The recommended dose of dutasteride is 0.5 mg once daily; do not chew the medication and do not administer to pediatric patients.

DRUG INTERACTIONS: Medications such as ketoconazole (Nizoral), cimetidine (Tagamet), diltiazem (Cardizem), verapamil (Calan), ritonavir (Norvir) and clarithromycin (Biaxin) slow down the breakdown of dutasteride. This may lead to increased levels of dutasteride in the body, increasing side effects such as decreased libido, erectile dysfunction, and impotence.

Medications such as carbamazepine (Tegretol) and primidone (Mysoline) increase the breakdown of dutasteride in the body. This may lead to decreased levels of dutasteride in the body, lowering the beneficial effects of the medication.

PREGNANCY: Dutasteride is not recommended to pregnant females because it can cause birth defects in the unborn child.

NURSING MOTHERS: It is not known whether dutasteride enters breast milk.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 12/22/2014
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