dutasteride (Avodart)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

Enlarged Prostate Treatment

GENERIC NAME: dutasteride

BRAND NAME: Avodart

DRUG CLASS AND MECHANISM: Dutasteride is a medication used for the treatment of benign prostatic hyperplasia (BPH) also known as an enlarged prostate. Dutasteride belongs to a class of medication called 5-alpa reductase inhibitors. Male hormone dihydrotestosterone (DHT) is primarily responsible for development and enlargement of the prostate gland. Testosterone is converted into DHT by 5-alpha reductase enzyme. Dutasteride blocks 5-alpha reductase enzyme and prevents excessive DHT production in the prostate gland. This delays the progression of an enlarged prostate and improves symptoms of BPH.

The FDA approved dutasteride in November 2001.

PRESCRIBED FOR: Dutasteride is used for the treatment of benign prostatic hyperplasia. It improves symptoms of enlarged prostate, reduces retaining of urine, and reduces the risk of the need for prostate surgery.

SIDE EFFECTS: Dutasteride causes many sexual side effects.

Common side effects are:

Allergic reaction such as swelling under the skin may occur.

Dutasteride also increases risk of high-grade prostate cancer.

Medically Reviewed by a Doctor on 12/22/2014
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