- Drug interactions overview
- What are drug interactions?
- How do drug interactions occur?
- Change in absorption
- Change in drug metabolism and elimination
- What are the consequences of drug interactions?
- How often do drug interactions occur?
- How can drug interactions be avoided?
Drug interactions overview
Whenever two or more drugs are being taken, there is a chance that there will be an interaction among the drugs. The interaction may increase or decrease the effectiveness of the drugs or their side effects. The likelihood of drug interactions increases as the number of drugs being taken increases. Therefore, people who take many drugs are at the greatest risk for interactions. Drug interactions contribute to the cost of healthcare because of the costs of medical care that are required to treat problems caused by changes in effectiveness or side effects. Interactions also can lead to psychological suffering. This review discusses the issue of drug interactions and several ways to avoid them.
What are drug interactions?
A drug interaction can be defined as an interaction between a drug and another substance that prevents the drug from performing as expected. This definition applies to interactions of drugs with other drugs (drug-drug interactions), as well as drugs with food (drug-food interactions) and other substances, such as supplements. Drugs also may interact with laboratory tests, changing the proper results of the laboratory test.
How do drug interactions occur?
There are several mechanisms by which drugs interact with other drugs, food, and other substances. An interaction can result when there is an increase or decrease in:
- the absorption of a drug into the body;
- distribution of the drug within the body;
- alterations made to the drug by the body (metabolism); and
- elimination of the drug from the body.
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