Drug Induced Liver Disease (cont.)

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What are the symptoms of liver disease?

Patients with mild liver disease may have few or no symptoms or signs. Patients with more serious disease develop symptoms and signs that may be nonspecific or specific.

Nonspecific symptoms (symptoms that also can be seen in other disorders) include:

Symptoms and signs that are specific for liver disease include:

  • yellowing of the skin (jaundice) due to the accumulation of bilirubin in the blood,
  • itching associated with liver disease, and
  • easy bruising due to decreased production of blood clotting factors by the diseased liver.

Severe, advanced liver disease with cirrhosis can produce symptoms and signs related to cirrhosis; these symptoms include:

  • fluid accumulation in the legs (edema) and abdomen (ascites, due to increased pressure in the vessels going into the liver),
  • mental confusion or coma (from hepatic encephalopathy due to increase in ammonia),
  • kidney failure,
  • vulnerability to bacterial infections, and
  • gastrointestinal bleeding, secondary to varices (enlarged blood vessels in the esophagus or stomach).
Medically Reviewed by a Doctor on 1/22/2014

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Drug-Induced Liver Disease - Describe Your Experience Question: The symptoms of drug-induced liver disease can vary greatly from patient to patient. What were your symptoms at the onset of your disease?
Drug-Induced Liver Disease - Causes Question: What caused your drug-induced liver disease?
Drug-Induced Liver Disease - Hepatitis Question: Did you have drug-induced hepatitis? Please describe your experience.
Drug-Induced Liver Disease - Cirrhosis Question: Were you or someone you know diagnosed with drug-induced cirrhosis? Please share your story.
Drug-Induced Liver Disease - Treatment Question: In addition to stopping the drug that caused liver disease, what types of treatment did you receive?