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February 10, 2012

Patient Discussions: Drug-Induced Liver Disease - Describe Your Experience

Question:The symptoms of drug-induced liver disease can vary greatly from patient to patient. What were your symptoms at the onset of your disease?

Comment from: TCB, 35-44 Male (Patient) Published: September 02

I was prescribed Diclofenac Sod 75mg and had side affect dark urine and I took about 10 pills. I went for something else now stressed about an elevated bilirubin and I also stop taking Simvastatin. I will change diet and exercise to lower cholesterol. I am still under going tests, but this is not worth the side affects.

Related Reading: Diclofenac | Simvastatin | cholesterol

Comment from: GIMS, 55-64 Female (Patient) Published: July 15

I started noticing sore nodules in the upper portion of the liver. My urine became dark, and I had decreased urine output. I had been having fatigue for a long time that was diagnosed as anxiety and depression. I am very sensitive to drugs and usually have at least 50% of the side effects of any drug. I am so sad because nobody wanted to listen to my sensitivity to drugs. I refused to take some drugs because I would rather die than live with the side effects. I have ended up with acute liver disease because of some of the drugs I am on. The doctor instantly took me off HCTZ, and I am still worried about Norvasc and Benicar.

Related Reading: liver | fatigue | anxiety

Comment from: Leo, 45-54 Male (Patient) Published: June 29

I am 52 with Hepatitis C and my next check up for that is a couple months away. Last month I had a hip resurface and have been on oxycodone. Now, I am not taking oxycodone because of the way it makes me feel and my pain is going away, except I need something to get me thru a nights sleep. My pain level is a lot better. My question is, what pain med over the counter or prescription is best for someone with Hepatitis C.

Related Reading: Hepatitis C | oxycodone | sleep

Comment from: Have FAITH, 35-44 Female (Patient) Published: June 29

I had a few glasses of wine one night, a few days later I became ill, feeling as though I had a flu but with stomach pains. I went to the doctor and she prescribed erythromycin (broad spectrum antibiotic) that night I collapsed on the floor in sever pain. I was taken to the ER where I was diagnosed with stomach pain and given (donnatal). When I returned home my sister (25miles away) called. The ER doctor had contacted my emergency contact as I was on the way home (in even more pain) he had over looked my labs, my alt and slt were elevated (in the thousands) and my pancreas was inflamed, he needed me to come back to the ER immediately. I did and went thru a series of tests and diagnosis on to finally discover that I had autoimmune hepatitis type I (a liver disease where your body attacks your liver) my symptoms were severe pain in my upper right rib cage, extreme fatigue, pale stool, itching, as best I can remember. I was also diagnosed with Hepatitis C and Sjroens syndrome therefore I couldn't be treated for the Hepatitis C. It would make the autoimmune hepatitis worse, so I was put on prednisone and something else but anyway I stopped taking all of it, started eating better and hydrating myself, got pregnant and my levels dropped back to normal. I now have two girls 5 and 2 and so far I feel really good. Let me make it clear that autoimmune hepatitis has a 10 year life expectancy and let me also make it clear that I would not be here today without the power of prayer and that's why I stopped the medications. It was a walk of faith.

Related Reading: flu | erythromycin | liver disease

Published: June 29

I am a 19 year old female. One day I just started feeling really queasy all the time and not really having much of an appetite, this went on for days and I started getting worried I was pregnant, then I started noticing my urine was a really dark brown, I started getting to the point where I couldn't keep anything down I then immediately drove myself to the ER. When the ER doctor saw me she then noticed the whites of my eyes were yellow and right there she said hepatitis. After hours of tests and being admitted I was then released the next night, still feeling the same as when I came in they said it was viral it will take awhile to go away. The next day I still felt horrible and couldn't hold anything down. I called my doctor and he said to go to Dallas so I rushed to Dallas where they had a good liver team and after more and more tests and after being there 3 days I had to get a liver biopsy where I was then diagnosed with autoimmune hepatitis. When I was in high school I was on multiple tetracycline's for my acne and my doctors realized this is what triggered my liver to do this and now I will be on prednisone and azathioprine for 22 months. So watch out to anybody taking tetracyclines because this could happen.

Related Reading: liver biopsy | tetracycline | acne


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Drug-Induced Liver Disease - Causes Question: What caused your drug-induced liver disease?

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Suggested Reading on Drug-Induced Liver Disease by Our Doctors

  • Related Diseases & Conditions

    • Abdominal Pain
      • Abdominal pain is pain in the belly and can be acute or chronic. Causes include inflammation, distention of an organ, and loss of the blood supply to an organ. Abdominal pain can reflect a major problem with one of the organs in the abdomen such as the appendix, gallbladder, large and small intestine, pancreas, liver, colon, duodenum, and spleen.
    • Cirrhosis (Liver)
      • Cirrhosis of the liver refers to a disease in which normal liver cells are replaced by scar tissue caused by alcohol and viral hepatitis B and C. This disease leads to abnormalities in the liver's ability to handle toxins and blood flow, causing internal bleeding, kidney failure, mental confusion, coma, body fluid accumulation, and frequent infections. Symptoms include yellowing of the skin, itching, and fatigue.
    • Liver Disease
      • Liver disease can be cause by a variety of things including infection (hepatitis), diseases such as gallstones, high cholesterol or triglycerides, blood flow obstruction to the liver, and toxins (medications and chemicals). Symptoms of liver disease depends upon the cause; however, common symptoms may include nausea, vomiting, upper right abdominal pain, and jaundice. Treatment depends upon the cause of the liver disease.
    • Hepatitis C
      • Hepatitis C is an inflammation of the liver due to the hepatitis C virus (HCV), which is usually spread by blood transfusion, hemodialysis, and needle sticks, especially with intravenous drug abuse. Chronic hepatitis C may be treated with interferon, usually in combination with anti-virals.
    • Jaundice
      • Jaundice is a yellowish staining of the skin and whites of the eyes (sclerae) with bilirubin, the pigment found in bile. Jaundice can be an indicator of liver or gallbladder disease, or it may result from the rupture of red blood cells (hemolysis).
    • Alcoholism
      • Alcoholism is a disease that includes alcohol craving and continued drinking despite repeated alcohol-related problems, such as losing a job or getting into trouble with the law.
    • Hepatitis B
      • The hepatitis B virus is a unique, coated DNA virus belonging to the Hepadnaviridae family of viruses. The course of the virus is determined primarily by the age at which the infection is acquired and the interaction between the virus and the body's immune system. Successful treatment is associated with a reduction in liver injury and fibrosis (scarring), a decreased likelihood of developing cirrhosis and its complications, including liver cancer, and a prolonged survival.
    • Liver
      • The liver is the largest solid organ in the body, and is actually an gland. The liver has a wide variety of critical functions such as manufacturing proteins and metabolizing fats and carbohydrates. The liver also eliminates harmful biochemical waste products from the body (alcohol, drugs, toxins). The liver secretes bile that aids in digestion. Examples of diseases of the liver include cirrhosis, hepatitis, cancer, and fatty liver. Symptoms of liver disease include bleeding, easy bruising, edema, fatigue, and jaundice.
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Symptom Checker: Your Guide to Symptoms & Signs: Pinpoint Your Pain


Drug-Induced Liver Disease

What is liver disease?

Liver disease is any disturbance of liver function that causes illness. The liver is responsible for many critical functions within the body and should it become diseased or injured, the loss of those functions can cause significant damage to the body. Liver disease is also referred to as hepatic disease.

Liver disease is a broad term that covers all the potential problems that may occur to cause the liver to fail to perform its designated functions. Usually, more than 75% or three quarters of liver tissue needs to be affected before decrease in function occurs.

The liver the largest solid organ in the body; and is also considered a gland because among its many functions, it makes and secretes bile. The liver is located in the upper right portion of the abdomen protected by the rib cage. It has two main lobes that are made up of tiny lobules. The liver cells have two different sources of blood supply. The hepatic ...

Read the Liver Disease article »




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