drotrecogin alfa-injectable, Xigris (cont.)

DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription medication you may use, especially: "blood thinners" (e.g., aspirin, heparin, warfarin, IIb/IIIa inhibitors), clot-dissolving drugs (e.g., thrombolytics such as alteplase, reteplase, urokinase). This drug may interfere with certain laboratory tests (e.g., activated partial thromboplastin times-aPTT). Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, stop the medication and contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include: severe bleeding problems (see Side Effects section).

NOTES: Do not share this medication with others. Laboratory and/or medical tests may be performed to monitor your progress.

MISSED DOSE: If a dose is stopped or interrupted, contact the doctor to establish a new dosing schedule/rate.

STORAGE: Store unmixed/powder vials in a refrigerator between 36 and 46 degrees F (2 and 8 degrees C) away from light. Do not freeze. Once mixed, the vials are good for 3 hours at room temperature (77 degrees F or 25 degrees C). Discard any unused portion of the vial(s). After mixing and subsequent dilution with IV fluids, this product must be used immediately and is stable at room temperature for 12 hours only.

Last Editorial Review: 3/2/2005

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