dronabinol (Marinol, THC)

  • Medical Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Cancer 101: Cancer Explained

Less common side effects include

Dronabinol is a controlled substance because it may be abused.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Oral capsules: 2.5, 5, and 10 mg

STORAGE: Dronabinol capsules should be stored in a cool location between 8 C and 15 C (46 F and 59 F ) or in the refrigerator. Capsules should not be frozen.

DOSING:

For appetite stimulation in AIDS patients

  • The general recommended starting dose is 2.5 mg by mouth twice daily, before lunch and dinner.
  • Patients who are having difficulty tolerating this dosage may take 2.5 mg once a day in the evening or at bedtime.
  • In patients who are tolerating dronabinol well, the dose may be slowly increased up to a maximum dose of 20 mg per day.

For nausea and vomiting

  • 5 mg per meter-squared of body surface (5 mg/m2) should be administered 1-3 hours before chemotherapy followed by repeated administration every 2 to 4 hours after chemotherapy for a total of 4 to 6 doses per day.
  • If needed, the dosage may be increased in 2.5 mg/m2 increments to a maximum of 15 mg/m2 per dose.

DRUG INTERACTIONS:

Although no drug-drug interactions were identified during clinical trials conducted by the manufacturer, dronabinol should be used cautiously with other medications that are known to interact with cannabinoids.

Medically Reviewed by a Doctor on 7/6/2015

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