dronabinol (Marinol, THC)

  • Medical Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is the dosage for dronabinol-oral?

For appetite stimulation in AIDS patients

  • The general recommended starting dose is 2.5 mg by mouth twice daily, before lunch and dinner.
  • Patients who are having difficulty tolerating this dosage may take 2.5 mg once a day in the evening or at bedtime.
  • In patients who are tolerating dronabinol well, the dose may be slowly increased up to a maximum dose of 20 mg per day.

For nausea and vomiting

  • 5 mg per meter-squared of body surface (5 mg/m2) should be administered 1-3 hours before chemotherapy followed by repeated administration every 2 to 4 hours after chemotherapy for a total of 4 to 6 doses per day.
  • If needed, the dosage may be increased in 2.5 mg/m2 increments to a maximum of 15 mg/m2 per dose.

Which drugs or supplements interact with dronabinol-oral?

:

Although no drug-drug interactions were identified during clinical trials conducted by the manufacturer, dronabinol should be used cautiously with other medications that are known to interact with cannabinoids.

People taking dronabinol should not drink alcohol, smoke marijuana, take sedatives and hypnotics, or take other medicines that have an effect on the central nervous system. Examples of drugs to avoid include diazepam (Valium), chlordiazepoxide (Librium), alprazolam (Xanax), secobarbital (Seconal), pentobarbital (Nembutal), and phenobarbital.

Medically Reviewed by a Doctor on 7/6/2015

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