doxycycline (Vibramycin, Oracea, Adoxa, Atridox, Acticlate, Doryx, and others)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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Tetracyclines, such as doxycycline, may cause tooth discoloration if used in persons below 8 years of age. Exaggerated sunburn can occur with tetracyclines; therefore, sunlight should be minimized during treatment.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Capsules: 40, 50, 75, 100and 150 mg; Tablets: 50, 75, 100 and 150 mg. Tablets (Delayed Release): 50, 75, 80, 100, 150, and 200 mg. Syrup: 50 mg/5 ml (teaspoon). Powder for injection: 100and 200 mg.

STORAGE:

  • Tablets, capsules, and syrup should be kept at room temperature 15 C to 30 C (59 F to 86 F) in tight, light resistant containers.
  • Powder for injection should be stored at or below 25 C (77 F) and protected from light.
  • Atridox (doxycycline in a gel used for subgingival application) should be stored at 2 C to 8 C (36 F to 46 F).

DOSING: The absorption of doxycycline is not markedly affected by food, and therefore, it can be taken with meals. For most infections, doxycycline is taken once or twice daily for 7 to 14 days. For adult infections, the usual dose of oral doxycycline is 200 mg on the first day of treatment (100 mg every 12 hours) followed by a dose of 100 to 200 mg/day as a single dose or divided and administered twice daily.

DRUG INTERACTIONS: It is recommended that doxycycline not be taken at the same time as aluminum, magnesium, or calcium based antacids, such as

because, like food, these medications bind doxycycline in the intestine and prevent its absorption. Similarly, doxycycline should not be taken with minerals (such as calcium or iron) or with bismuth subsalicylate (Pepto Bismol).

Doxycycline may enhance the activity of warfarin (Coumadin) and cause excessive "thinning" of the blood leading to exaggerated bleeding, necessitating a reduction in the dose of warfarin. Phenytoin (Dilantin), carbamazepine (Tegretol), and barbiturates (such as phenobarbital) may enhance the metabolism (destruction) of doxycycline thus making it less effective.

Medically Reviewed by a Doctor on 4/13/2015

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