doxepin (Sinequan and Adapin are discontinued brand in the US; Silenor) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:
Medical and Pharmacy Editor:

SIDE EFFECTS: The most common side effect of doxepin is drowsiness. Drowsiness improves as therapy continues. Other side effects associated with doxepin include blurred vision, urinary retention (difficulty urinating), dry mouth, constipation, weight gain or loss, and low blood pressure when rising from a sitting position (orthostatic hypotension). Rash, hives, rapid or irregular heart rates, seizures, and hepatitis are rare side effects.

Doxepin also can cause elevated pressure in the eyes of some patients with glaucoma.

If antidepressants, including doxepin, are discontinued abruptly, symptoms such as dizziness, headache, nausea, and changes in mood may occur. Such symptoms of withdrawal may occur even when a few doses of antidepressant are missed. Therefore, it is recommended that the dose of antidepressant be reduced gradually when therapy is discontinued.

Antidepressants increased the risk of suicidal thinking and behavior in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of any antidepressant in a child or adolescent must balance this risk with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thinking or behavior, and unusual changes in behavior.

Reference: FDA Prescribing Information


Medically Reviewed by a Doctor on 10/21/2014


Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.


Back to Medications Index