GENERIC NAME: doxepin
BRAND NAME: Silenor
DISCONTINUED BRANDS: Sinequan, Adapin
DRUG CLASS AND MECHANISM: Doxepin belongs to a class of drugs called tricyclic antidepressants (TCAs) that are used primarily to treat depression and anxiety. Other examples of TCAs include amitriptyline (Elavil), nortriptyline (Pamelor), desipramine (Norpramin), and several others. Depression is an all-pervasive sense of sadness and gloom. In some patients with depression, an imbalance in levels of neurotransmitters in the brain may be the cause of the depression. Neurotransmitters are chemicals that nerves use to communicate with each other. Neurotransmitters affected by doxepin include serotonin, norepinephrine, acetylcholine, and histamine. Doxepin may elevate mood by raising the levels of serotonin and norepinephrine. It also blocks the activity of acetylcholine and histamine. The FDA approved doxepin in March 1974.
PRESCRIBED FOR: Doxepin is used for treating depression, anxiety and insomnia. It also is used for treating depression due to alcoholism or brain damage, and depression associated with bipolar disorder.
Quick GuideMigraine or Headache? Migraine Symptoms, Triggers, Treatment
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.