doxazosin mesylate, Cardura (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 1, 2, 4, and 8 mg. Tablets (Extended Release): 4, 8 mg
STORAGE: Doxazosin should be stored at room temperature, 15-30 C (59-86 F).
PRESCRIBED FOR: Doxazosin is used for the treatment of hypertension (high blood pressure) and benign prostatic hyperplasia (BPH).
DOSING: The recommended dose of doxazosin for hypertension is 1-16 mg daily. The recommended dose for benign prostatic hyperplasia is 1-8 mg daily.
DRUG INTERACTIONS: Vardenafil (Levitra) or tadalafil (Cialis) and doxazosin have additive blood pressure lowering effects. Combining vardenafil or tadalafil (Cialis) with doxazosin may cause excessive blood pressure reduction.
PREGNANCY: There are no adequate studies of doxazosin in pregnant women.
NURSING MOTHERS: There are no adequate studies of doxazosin in nursing mothers.
SIDE EFFECTS: Common reactions include dizziness, fatigue, headache, shortness of breath, diarrhea, abdominal pain, edema (fluid accumulation) and low blood pressure. Doxazosin causes significant reduction in blood pressure after administration of the first dose (first dose effect). This reduction in blood pressure may be associated with dizziness and fainting, especially when rising from a sitting position. To avoid this, patients should rise slowly from a sitting position, start treatment with the 1 mg dose, and then doses should be adjusted upwards slowly. Priapism (painful, prolonged penile erection) and a reduction in white blood cells have been associated with doxazosin.
Doxazosin can cause intraoperative floppy iris syndrome (IFIS) during cataract surgery. Patients should inform their eye surgeon that they are taking doxazosin.
Reference: FDA Prescribing Information
Last Editorial Review: 7/13/2010
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