dorzolamide, Trusopt (cont.)

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Medical and Pharmacy Editor:

DRUG INTERACTIONS: Dorzolamide should not be administered with oral carbonic anhydrase inhibitors because the combination may lead to increased adverse effects. When used with other eye drops for reducing intraocular pressure, administration of both drugs should be separated by at least10 minutes.

PREGNANCY: There have been no adequate studies in pregnant women.

NURSING MOTHERS: It is not known if dorzolamide is excreted into breast milk.

SIDE EFFECTS: The most common side effects of dorzolamide include irritation, burning, stinging or discomfort of the eye. These effects generally are temporary and occur immediately after administration. Approximately 1 in 4 patients complain of a bitter taste, and 1 in 10 patients experience an allergic eye reaction or eye inflammation (superficial punctate keratitis). Other less common side effects include blurred vision, excessive tearing, dry eyes, and increased sensitivity to light. Bacterial infections of the eye have been reported and may be due to accidental contamination of the containers with bacteria during handling. Dorzolamide is a sulfonamide and can be absorbed into the body. Individuals who are allergic to sulfonamides may react to dorzolamide. Therefore, dorzolamide should not be administered to patients with allergies to sulfonamides, and it can cause some of the side effects of sulfonamides. Severe skin reactions also have been reported.

Reference: FDA Prescribing Information

Last Editorial Review: 3/7/2013

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