dorzolamide, Trusopt (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC AVAILABLE: Yes
PREPARATIONS: Ophthalmic solution 2%: 10 ml.
STORAGE: Dorzolamide should be kept at room temperature, 15 C to 30 C (59 F to 86 F), and protected from direct light.
DOSING: The usual dose is one drop into the affected eye(s) three times daily.
Patients should wash both hands before each use of dorzolamide or any other eye medication to prevent contamination of the eye. Contact lenses should be removed since dorzolamide solution contains benzalkonium chloride which can be absorbed by contact lenses. The head is tilted back, and the lower eyelid is pulled down with the index finger to form a pouch. The bottle is squeezed slightly to allow the prescribed number of drops into the pouch. The tip of the dropper should not touch the eye or eyelid. The eye then is closed gently for one to two minutes without blinking.
DRUG INTERACTIONS: Dorzolamide should not be administered with oral carbonic anhydrase inhibitors because the combination may lead to increased adverse effects. When used with other eye drops for reducing intraocular pressure, administration of both drugs should be separated by at least10 minutes.
PREGNANCY: There have been no adequate studies in pregnant women.
NURSING MOTHERS: It is not known if dorzolamide is excreted into breast milk.
SIDE EFFECTS: The most common side effects of dorzolamide include irritation, burning, stinging or discomfort of the eye. These effects generally are temporary and occur immediately after administration. Approximately 1 in 4 patients complain of a bitter taste, and 1 in 10 patients experience an allergic eye reaction or eye inflammation (superficial punctate keratitis). Other less common side effects include blurred vision, excessive tearing, dry eyes, and increased sensitivity to light. Bacterial infections of the eye have been reported and may be due to accidental contamination of the containers with bacteria during handling. Dorzolamide is a sulfonamide and can be absorbed into the body. Individuals who are allergic to sulfonamides may react to dorzolamide. Therefore, dorzolamide should not be administered to patients with allergies to sulfonamides, and it can cause some of the side effects of sulfonamides. Severe skin reactions also have been reported.
Reference: FDA Prescribing Information
Last Editorial Review: 3/7/2013
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