dorzolamide, Trusopt

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GENERIC NAME: dorzolamide


DRUG CLASS AND MECHANISM: Dorzolamide is an ophthalmic solution (a liquid that is placed in the eyes) that is used for treating glaucoma. It is in a class of drugs called carbonic anhydrase inhibitors which also includes brinzolamide (Azopt). Many parts of the body, including the eye, contain the enzyme carbonic anhydrase. Carbonic anhydrase controls secretion of fluid within the eye and thereby determines the pressure within the eye (intraocular pressure); the greater the amount of fluid that is secreted, the higher the pressure. Patients with glaucoma have increased intraocular pressure. Dorzolamide blocks carbonic anhydrase thereby decreasing secretion of fluid and intraocular pressure. This reduces the risk of nerve damage and loss of vision that is caused by increased intraocular pressure in patients with glaucoma. The FDA approved dorzolamide in December 1994.



PREPARATIONS: Ophthalmic solution 2%: 10 ml.

STORAGE: Dorzolamide should be kept at room temperature, 15 C to 30 C (59 F to 86 F), and protected from direct light.

PRESCRIBED FOR: Dorzolamide is used for controlling intraocular pressure in patients with ocular hypertension (glaucoma).

DOSING: The usual dose is one drop into the affected eye(s) three times daily.

Patients should wash both hands before each use of dorzolamide or any other eye medication to prevent contamination of the eye. Contact lenses should be removed since dorzolamide solution contains benzalkonium chloride which can be absorbed by contact lenses. The head is tilted back, and the lower eyelid is pulled down with the index finger to form a pouch. The bottle is squeezed slightly to allow the prescribed number of drops into the pouch. The tip of the dropper should not touch the eye or eyelid. The eye then is closed gently for one to two minutes without blinking.

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