dornase alpha, Pulmozyme (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

SIDE EFFECTS: The most common side effects of dornase alpha include:



PREPARATIONS: Single-use ampules; 2.5 ml (1 mg/ml)

STORAGE: Dornase alpha must be kept in a refrigerator at 2 C to 8 C (36 F to 46 F) and protected from direct sunlight. The solution should be thrown away if it is cloudy or discolored. Since the ampule does not contain a preservative, the entire contents of the ampule must be used or thrown away after it is opened.

DOSING: The recommended dose is one ampule (2.5 ml) inhaled once or twice daily using a recommended nebulizer.

DRUG INTERACTIONS: Drug interaction studies have not been conducted. Dornase alpha is compatible with standard cystic fibrosis therapies including oral, inhaled and/or parenteral antibiotics, bronchodilators, enzyme supplements, vitamins, oral or inhaled corticosteroids, and analgesics.

PREGNANCY: No damage has been noted to fetuses of pregnant animals exposed to high doses of dornase alpha. However, there are no studies in women. Therefore, physicians must weigh potential risks with the expected benefits of therapy when deciding whether or not to use dornase alpha in pregnancy.

Medically Reviewed by a Doctor on 6/17/2015

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