- Heartburn Slideshow: Foods to Eat, Foods to Avoid
- 10 Facts About the Amazing Brain
- Weight Gain Shockers Slideshow Pictures
- What is dornase alpha, and how does it work (mechanism of action)?
- What brand names are available for dornase alpha?
- Is dornase alpha available as a generic drug?
- Do I need a prescription for dornase alpha?
- What are the side effects of dornase alpha?
- What is the dosage for dornase alpha?
- Which drugs or supplements interact with dornase alpha?
- Is dornase alpha safe to take if I'm pregnant or breastfeeding?
- What else should I know about dornase alpha?
What is dornase alpha, and how does it work (mechanism of action)?
Dornase alpha is an inhaled drug for treating cystic fibrosis, a lung disease which is the most common fatal genetic disease in developed countries. The lungs continually secrete fluid into the airways to keep them moist. In cystic fibrosis, the fluid becomes thick because the amount of water it contains is reduced. The thickened fluid is difficult to cough up or spit out. It blocks the airways, making breathing difficult and promoting the growth of bacteria and infection. Infection destroys the tissues of the lungs, and it is the slowly progressive destruction of the lungs that is the major cause of disability and death in children with cystic fibrosis. The thick fluid contains high concentrations of deoxyribonucleic acid (DNA). Dornase alpha is a genetically engineered form of the human enzyme, deoxyribonuclease or DNAse. Dornase alpha breaks down the DNA and thereby reduces the thickness of the fluids. Dornase alpha was approved by the FDA in 1993.
What brand names are available for dornase alpha?
Is dornase alpha available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for dornase alpha?
What are the side effects of dornase alpha?
The most common side effects of dornase alpha include:
- voice alteration,
- sore throat,
- chest pain,
- red eyes,
- nasal congestion,
- shortness of breath,
- stomach upset,
- and fever.
Quick GuidePrescription Drug Abuse: Know The Warning Signs
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.